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Título: Organocatalytic cascade reaction for the synthesis of polycylic compounds utilizing Trienamine activation
Autor: SUHAS BALASAHEB MITKARI
ID del Autor: info:eu-repo/dai/mx/cvu/787089
Resumen: We report an Aminocatalytic privileged Diversity-Oriented Synthesis (ApDOS) strategy via trienamine catalysis for the construction of diverse and complex thiopyrans-piperidone fused rings through a thia-Diels–Alder/nucleophilic ring closing sequence by using dithioamides as activated heterodienophiles. Following this strategy, a super cascade reaction to assemble nine fused rings can be achieved by employing a bis-dithioamide. Additionally, by linking an indole moiety on the dithioamide, a Pictet-Spengler type reaction can be promoted once the cascade sequence has been achieved, leading to more complex penta- hexa- and heptacyclic fused ring derivatives in a one-pot process. This investigation, open new perspectives for the synthesis of a new class of complex and diverse thiopyrans, which contribute to populate new relevant regions in the chemical space.
Fecha de publicación: 2021
Editorial: Universidad de Guanajuato
Licencia: http://creativecommons.org/licenses/by-nc-nd/4.0
URI: http://repositorio.ugto.mx/handle/20.500.12059/5166
Idioma: eng
Aparece en las colecciones:Doctorado en Química

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