Please use this identifier to cite or link to this item: http://repositorio.ugto.mx/handle/20.500.12059/5166
Title: Organocatalytic cascade reaction for the synthesis of polycylic compounds utilizing Trienamine activation
Authors: SUHAS BALASAHEB MITKARI
Authors' IDs: info:eu-repo/dai/mx/cvu/787089
Abstract: We report an Aminocatalytic privileged Diversity-Oriented Synthesis (ApDOS) strategy via trienamine catalysis for the construction of diverse and complex thiopyrans-piperidone fused rings through a thia-Diels–Alder/nucleophilic ring closing sequence by using dithioamides as activated heterodienophiles. Following this strategy, a super cascade reaction to assemble nine fused rings can be achieved by employing a bis-dithioamide. Additionally, by linking an indole moiety on the dithioamide, a Pictet-Spengler type reaction can be promoted once the cascade sequence has been achieved, leading to more complex penta- hexa- and heptacyclic fused ring derivatives in a one-pot process. This investigation, open new perspectives for the synthesis of a new class of complex and diverse thiopyrans, which contribute to populate new relevant regions in the chemical space.
Issue Date: 2021
Publisher: Universidad de Guanajuato
License: http://creativecommons.org/licenses/by-nc-nd/4.0
URI: http://repositorio.ugto.mx/handle/20.500.12059/5166
Language: eng
Appears in Collections:Doctorado en Química

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