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http://repositorio.ugto.mx/handle/20.500.12059/11954Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.rights.license | http://creativecommons.org/licenses/by-nc-nd/4.0 | es_MX |
| dc.creator | Luis A. Segura-Quezada | es_MX |
| dc.date.accessioned | 2024-06-28T17:53:50Z | - |
| dc.date.available | 2024-06-28T17:53:50Z | - |
| dc.date.issued | 2024 | - |
| dc.identifier.issn | 2007-672X | es_MX |
| dc.identifier.uri | http://repositorio.ugto.mx/handle/20.500.12059/11954 | es_MX |
| dc.description.abstract | Uno de los antiinflamatorios no esteroideos más importantes (AINE) que contiene el núcleo de indol está representado por la indometacina. Este compuesto de gran relevancia se ha utilizado durante los últimos 50 años con excelentes resultados farmacológicos. Pendiente a su relevante eficacia como tratamiento antiinflamatorio, varias síntesis se han desarrollado durante esta mitad de siglo. Aquí se resume y discute la mayoría estrategias representativas que abordaron con éxito la síntesis total de indometacina, así como algunos de sus derivados generado al realizar modificaciones estratégicas en el átomo de nitrógeno, el ácido carboxílico en C-3, el grupo metoxi en C-5 y el grupo metilo en C-2. | es_MX |
| dc.language.iso | spa | es_MX |
| dc.publisher | Universidad de Guanajuato | es_MX |
| dc.relation | http://www.naturalezaytecnologia.com/index.php/nyt/article/view/537 | es_MX |
| dc.rights | info:eu-repo/semantics/openAccess | es_MX |
| dc.source | Naturaleza y Tecnología". Enero-Abril 2024, Vol. 11, Núm. 1 (2024). | es_MX |
| dc.title | Síntesis de indometacina: Una revisión histórica | es_MX |
| dc.title.alternative | Synthesis of indomethacin: A hystoric review | en |
| dc.type | info:eu-repo/semantics/article | es_MX |
| dc.creator.id | info:eu-repo/dai/mx/orcid/0000-0003-2179-9678 | es_MX |
| dc.subject.cti | info:eu-repo/classification/cti/2 | es_MX |
| dc.subject.cti | info:eu-repo/classification/cti/23 | es_MX |
| dc.subject.cti | info:eu-repo/classification/cti/2302 | es_MX |
| dc.subject.keywords | Indometacina | es_MX |
| dc.subject.keywords | Síntesis | es_MX |
| dc.subject.keywords | AINE (Antiinflamatorio No Esteroideo) | es_MX |
| dc.subject.keywords | Indomethacin | en |
| dc.subject.keywords | Synthesis | en |
| dc.subject.keywords | NSAID (Nonsteroidal Anti-Inflammatory Drugs) | en |
| dc.type.version | info:eu-repo/semantics/publishedVersion | es_MX |
| dc.creator.two | César Rogelio Solorio Alvarado | es_MX |
| dc.creator.idtwo | info:eu-repo/dai/mx/orcid/0000-0001-6082-988X | es_MX |
| dc.description.abstractEnglish | One of the most important non-steroidal anti-inflammatory drugs (NSAID) containing the indol core is represented by the indomethacin. This highly relevant compound has been used for the last 50 years with excellent pharmacological results. Due to its relevant efficacy as an anti-inflammatory treatment, several syntheses have been developed during this half of century. Herein is summarized and discussed the most representative strategies which successfully addressed the total syntheses of indomethacin as well as some of its derivatives generated by carrying out strategic modifications at the nitrogen atom, the carboxylic acid at C-3, the methoxy group at C-5 and the methyl group at C-2. | en |
| Appears in Collections: | Revista Naturaleza y Tecnología | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| SÍNTESIS DE INDOMETACINA UNA REVISIÓN HISTÓRICA.pdf | 1.18 MB | Adobe PDF | View/Open |
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